Zollinger-Ellison Syndrome (ZES) is a rare but significant condition characterized by excessive gastric acid production, frequently resulting from gastrin-secreting tumors known as gastrinomas. Residents in Queens, Levittown, and throughout Long Island experiencing chronic digestive issues may find themselves seeking specialized gastrointestinal care. At The GI Practice, our experienced team, including board-certified gastroenterologists Dr. Mit Shah, MD, and Dr. Davinder Singh, MD, is dedicated to providing comprehensive evaluation and treatment options for individuals suffering from ZES and its effects on health and wellness.
I had a pleasant experience at this office. Dr. Shah was very professional, kind and knowledgeable. The office is very clean and welcoming. The staff is friendly and make you feel relaxed. Very easy to schedule procedures and the wait time is very short. I highly recommend them.
What Is Zollinger-Ellison Syndrome and Its Causes
Zollinger-Ellison Syndrome primarily arises from gastrinomas, which are tumors that produce the hormone gastrin. Elevated gastrin levels lead to increased gastric acid secretion, which can cause severe complications including peptic ulcer disease. Approximately 60% of these tumors are cancerous and may spread to the liver and nearby lymph nodes. Conditions such as Multiple Endocrine Neoplasia Type 1 (MEN 1) can also be associated with gastrinomas, contributing to the complexities of this syndrome. Understanding the underlying causes is essential for effective management of this disorder.
Recognizing Symptoms of Zollinger-Ellison Syndrome
Individuals with Zollinger-Ellison Syndrome often present with a range of severe symptoms that can significantly impact their quality of life. Typical symptoms include:
- Severe abdominal pain
- Persistent diarrhea
- Acid-related issues including heartburn
- Refractory peptic ulcer disease
- Ulcers in the stomach and small intestine
Recognizing these symptoms early can lead to prompt evaluation and intervention, which is vital for managing the effects of excessive gastric acid production.
Available Treatment Options for Zollinger-Ellison Syndrome
Managing Zollinger-Ellison Syndrome involves a multidisciplinary approach focused on symptom relief and acid suppression. Treatment options typically include:
- Proton pump inhibitors (PPIs) like omeprazole
- Histamine receptor antagonists to further reduce stomach acid
- Surgical interventions for localized gastrinomas that have not metastasized
- Close monitoring and management of related conditions such as peptic ulcers and gastritis
Our gastroenterology practice provides comprehensive treatment strategies that can be tailored to each patient’s individual needs, ensuring optimal management of their condition.

How Our Long Island Practice Evaluates Gastrinomas
At The GI Practice, we employ advanced diagnostic techniques to evaluate potential gastrinomas effectively. Our evaluation process typically includes:
- Comprehensive laboratory tests to measure gastrin levels
- Imaging studies such as CT scans or MRI to locate gastrinomas
- Endoscopic procedures, if necessary, to directly visualize abnormalities in the gastrointestinal tract
This thorough approach ensures that patients receive an accurate diagnosis and the most effective treatment options available.
The Role of Proton Pump Inhibitors in Treatment
Proton pump inhibitors are essential in managing Zollinger-Ellison Syndrome as they directly combat gastric acid hypersecretion. By inhibiting the gastric proton pump, these medications significantly reduce acid production, leading to symptom relief and improved quality of life. Our physicians are experienced in determining the appropriate dosages and monitoring the effectiveness of these treatments as part of a comprehensive care strategy.
Understanding Gastric Acid Hypersecretion in Patients
Gastric acid hypersecretion can lead to various complications that may affect digestive function and overall health. It’s crucial for patients experiencing symptoms associated with ZES to seek specialized care. The team at our Long Island practice is well-versed in managing the intricate details of gastric acid disorders, ensuring that our patients receive expert advice and treatment tailored to their specific requirements.
Zollinger-Ellison Syndrome FAQs for Our Patients
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Zollinger-Ellison Syndrome is primarily caused by gastrin-secreting tumors known as gastrinomas, which lead to excessive gastric acid production.
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Diagnosis typically involves blood tests to measure gastrin levels, imaging studies, and sometimes endoscopy to assess symptoms and locate gastrinomas.
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Treatment options include proton pump inhibitors, histamine receptor antagonists, and surgical options for localized gastrinomas.
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Common symptoms include severe abdominal pain, diarrhea, and unusual ulcers in the stomach or small intestine.

Why Choose Our Gastroenterology Practice for Care
Our gastroenterology practice stands out for its commitment to providing evidence-based, patient-centered care. Led by Dr. Mit Shah and Dr. Davinder Singh, both board-certified gastroenterologists, our team brings extensive training and leadership experience from renowned institutions. We offer:
- Board-certified physicians with a focus on complex gastrointestinal disorders
- Advanced diagnostic and therapeutic endoscopic procedures
- Personalized treatment plans based on individual patient needs
- Convenient locations in Queens and Levittown for accessible care
Patients seeking care for Zollinger-Ellison Syndrome can trust our practice’s comprehensive approach to their health challenges. Contact our award-winning team today.
About UsSchedule Your Consultation in Queens or Levittown
To effectively manage your Zollinger-Ellison Syndrome and explore tailored treatment options, schedule your consultation with our skilled team in Queens or Levittown today. With years of experience and dedication to patient care, we are here to support your health and wellness journey.